In vitro Scolicidal Effect of Ginger (Zingiber officinale Roscoe) Ethanolic Extract Against Protoscolices of Hydatid Cyst

Authors

  • Elham Houshmand 1Department of Parasitology, Faculty of Veterinary Medicine, Rasht Branch, Islamic Azad University, Rasht, Iran
  • Hossein Elmi 3Department of Vet Bacteriology, Rasht Branch, Islamic Azad University, Rasht, Iran
Abstract:

Background: To prevent the recurrence of hydatid cysts after surgery, it is essential to use effective scolicidal agents. Most of these agents are not safe due to their undesired side effects. Recently, studies have been conducted to find natural scolicidal agents with more efficacies and low side effects. OBJECTIVES: In this study, the in vitro scolicidal effect of ethanolic extract of ginger (Z.officinale) on protoscolices of hydatid cyst was investigated. METHODS: A certain number of protoscolices (about 500) were treated with various concentrations of ginger ethanolic extract (40, 50, 100, 150 and 200 mg/ml) and the effect of each concentration was evaluated for specified time periods (15, 30, 45 and 60 minutes). Each concentration/time was performed in triplicate and the viability of protoscolices was confirmed by 0.1% eosin staining. RESULTS: The mortality rate with ethanolic extract of Z.officinale after 60 minutes was as follows:  68%, 92.3%, 93% and 100% at 50, 100, 150 and 200 mg/ml, respectively, and there was no significant difference between the three concentrations of 200, 150 and 100 mg/ml (P>0.05). However, at the concentrations of 200 mg/ml after 30 minutes of incubation, 100% protoscolices were dead. Based on Tukey’s test, a significant difference in the percentage of live protoscolices was found between the different concentrations of ginger extract with the exception of between 150 and 100 mg/ml concentrations (P>0.05). CONCLUSIONS: Ethanolic extract of Zingiber officinale had a high scolicidal activity in vitro, and it has the potential to be used as a scolicidal agent in the surgical treatment of hydatid cysts.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

ANTIBACTERIAL AND ANTI-BIOFILM ACTIVITY OF GINGER (Zingiber officinale (Roscoe)) ETHANOLIC EXTRACT

The antibacterial and anti-biofilm activity of ethanolic extract from the rhizome of Zingiber officinale were evaluated. In vitro antibacterial activity was investigated by microdilution method. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) have been determined. The values were in the range from 0.0024 to > 20 mg/ml. The most sensitive bacteria were Gram-po...

full text

Scolicidal activity of zinc oxide nanoparticles against hydatid cyst protoscolices in vitro

Objective(s): Nanoparticles (NPs) are particles with the size range approximately from 1 to 100 nanometers that are made in different shapes. Nanotechnology is an emerging technology that expected to open some new opportunities in order to destroy and control of microorganisms using of materials and systems at the scale of the atom. Echinococcus granulosus is the agent of cystic echinococcosis ...

full text

In vitro evaluation of anti-Alzheimer effects of dry ginger (Zingiber officinale Roscoe) extract.

As the disease modifying therapies against Alzheimer's disease (AD) continue to exist as a major challenge of this century, the search for newer drug leads with lesser side effects is on the rise. A large number of plant extracts and phytocompounds are being actively pursued for their anti-Alzheimer effects. In the present study, the antioxidant activity, cholinesterase inhibition, anti-amyloid...

full text

Effect of ethanolic extract of Zingiber officinale Roscoe on Central Nervous System activity in mice

Zingiber officinale Roscoe, commonly known as ginger, is a traditional herb used to treat various disorders. In this study, we evaluated potential pharmacological effects of ethanolic extracts of Z. Officinale with respect to central nervous system (CNS) activity in mice. Role of ethanolic extract of ginger on CNS activity in mice was studied using models of elevated plus maze test, barbiturate...

full text

Sumac (Rhus coriaria L.): Scolicidal Activity on Hydatid Cyst Protoscolices

Background: Few anthelmintics are available for the treatment of hydatid disease caused by the parasite Echinococcus granulosus. The appearance of resistance to synthetic anthelmintics and the adverse side effects of chemical drugs, stimulated the research of alternatives, such as medicinal plants. In the present study, the scolicidal effect of methanolic extract of sumac (Rhus coriaria) was in...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 13  issue 1

pages  87- 99

publication date 2019-02-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023